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Shape based identification of proteins in volume images

  • Gunilla Borgefors
  • , Ida-Maria Sintorn

    Publikation: Kapitel i bok/rapport/konferenshandlingKonferensartikel i proceedingsPeer review

    Sammanfattning

    A template based matching method, adapted to the application of identifying individual proteins of a certain kind in volume images, is presented. Grey-level and gradient megnitude information is combined in the watershed algorithm to extract stable borders. These are used in a subsequent hierarchical matching algorithm. The matching algorithm uses a distance transform to serach for local best fits between the edges of a template and edges in the underlying image. It is embedded in a resolution pyramid to decrease the risk of getting stuck in false local minima. This method makes it possible to find proteins attached to other proteins, or proteins appearing as split into parts in the images. It also decreases the amount of human interaction m´needed for identifying individual proteins of the searched kind. The method is demonstrated on a set of three volume images of the antibody IgG in solution
    OriginalspråkEngelska
    Titel på värdpublikation14th Scandinavian Conference on Image Analysis, SCIA 2005
    Sidor253-262
    Antal sidor10
    StatusPublicerad - 2005

    Publikationsserier

    SerieLecture Notes in Computer Science
    Volym3540
    ISSN0302-9743

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