Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

Janine Winkler; Ya Xu; Yun Yun Gong; Johanna Lindahl; Susanne Kersten; Sven Daenicke; Michael N. Routledge

doi:10.1007/s12550-019-00383-7

Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

Janine Winkler
, Ya Xu
, Yun Yun Gong
, Johanna Lindahl
, Susanne Kersten
, Sven Daenicke
, Michael N. Routledge

Publikation: Bidrag till tidskrift › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.

Originalspråk	Engelska
Sidor (från-till)	207-211
Antal sidor	5
Tidskrift	Mycotoxin Research
Volym	36
Nummer	2
DOI	https://doi.org/10.1007/s12550-019-00383-7
Status	Publicerad - 2020
Externt publicerad	Ja

Nyckelord

Aflatoxin-albumin adduct
Biomarker
Aflatoxin M-1
ELISA
Dairy cow

Åtkomst av dokument

10.1007/s12550-019-00383-7

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title = "Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows",

abstract = "The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.",

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AU - Winkler, Janine

AU - Xu, Ya

AU - Gong, Yun Yun

AU - Lindahl, Johanna

AU - Kersten, Susanne

AU - Daenicke, Sven

AU - Routledge, Michael N.

PY - 2020

Y1 - 2020

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KW - ELISA

KW - Dairy cow

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KW - ELISA

KW - Dairy cow

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