On the reactivity of 2-methylene-3-quinuclidinone in water

Rune Ringom; Tim Blizzard; Corine Sandström; Per H. Svensson; Lars Hagberg

doi:10.3987/COM-22-14797

On the reactivity of 2-methylene-3-quinuclidinone in water

Rune Ringom
, Tim Blizzard
, Corine Sandström
, Per H. Svensson
, Lars Hagberg

Institutionen för molekylära vetenskaper

Publikation: Bidrag till tidskrift › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

The biologically active Michael acceptor 2-methylene-3-quinuclidinone (MQ) has a unique chemical reactivity and forms several products upon dissolution in water. With the use of X-ray, NMR and LCMS data the structures of two previously incorrectly characterised compounds are rectified. A complex equilibrium in water, containing novel dimeric species of MQ, and its dependence on temperature, pH and concentration is presented.

Originalspråk	Engelska
Sidor (från-till)	271-276
Antal sidor	6
Tidskrift	Heterocycles
Volym	106
Nummer	2
DOI	https://doi.org/10.3987/COM-22-14797
Status	Publicerad - 2023

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10.3987/COM-22-14797

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title = "On the reactivity of 2-methylene-3-quinuclidinone in water",

abstract = "The biologically active Michael acceptor 2-methylene-3-quinuclidinone (MQ) has a unique chemical reactivity and forms several products upon dissolution in water. With the use of X-ray, NMR and LCMS data the structures of two previously incorrectly characterised compounds are rectified. A complex equilibrium in water, containing novel dimeric species of MQ, and its dependence on temperature, pH and concentration is presented.",

author = "Rune Ringom and Tim Blizzard and Corine Sandstr{\"o}m and Svensson, \{Per H.\} and Lars Hagberg",

year = "2023",

doi = "10.3987/COM-22-14797",

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pages = "271--276",

journal = "Heterocycles",

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T1 - On the reactivity of 2-methylene-3-quinuclidinone in water

AU - Ringom, Rune

AU - Blizzard, Tim

AU - Sandström, Corine

AU - Svensson, Per H.

AU - Hagberg, Lars

PY - 2023

Y1 - 2023

N2 - The biologically active Michael acceptor 2-methylene-3-quinuclidinone (MQ) has a unique chemical reactivity and forms several products upon dissolution in water. With the use of X-ray, NMR and LCMS data the structures of two previously incorrectly characterised compounds are rectified. A complex equilibrium in water, containing novel dimeric species of MQ, and its dependence on temperature, pH and concentration is presented.

AB - The biologically active Michael acceptor 2-methylene-3-quinuclidinone (MQ) has a unique chemical reactivity and forms several products upon dissolution in water. With the use of X-ray, NMR and LCMS data the structures of two previously incorrectly characterised compounds are rectified. A complex equilibrium in water, containing novel dimeric species of MQ, and its dependence on temperature, pH and concentration is presented.

UR - https://res.slu.se/id/publ/123432

U2 - 10.3987/COM-22-14797

DO - 10.3987/COM-22-14797

M3 - Journal article

SN - 0385-5414

VL - 106

SP - 271

EP - 276

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -