Molecular analysis and characterization of swine and human influenza viruses isolated in Hungary in 2006–2007

In order to provide additional information to the epidemiological situation in Middle Europe and open further possibilities to investigate the transmission of influenza viruses between species, the viral genomes of three influenza A virus isolates (one human and two swine) collected from North-East Hungary in 2006–2007 have been fully sequenced and characterized. The sequence analysis reveals strong geographical relationships between the internal genes of the two swine viruses; the human isolate shows strict conservation to recent H1N1 strains, while the swine strains demonstrate and reflect a mixed avian–human origin, a characteristic of European swine influenza viruses. No evidence of interspecies interaction has been found among the studied isolates