Ljungvall K, Spjuth L, Hulten F, Einarsson S, Rodriguez-Martinez H, Andersson K, Magnusson U. 2006

Karl Ljungvall; Linda Spjuth; Fredrik Hulten; Stig Einarsson; Heriberto Rodriguez; Kjell Andersson; Ulf Magnusson

doi:10.1016/j.reprotox.2005.07.012

Ljungvall K, Spjuth L, Hulten F, Einarsson S, Rodriguez-Martinez H, Andersson K, Magnusson U. 2006

Karl Ljungvall
, Linda Spjuth
, Fredrik Hulten
, Stig Einarsson
, Heriberto Rodriguez
, Kjell Andersson
, Ulf Magnusson

Publikation: Bidrag till tidskrift › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

In a split-litter design experiment, boars were exposed orally three times weekly to 300 mg/kg of di(2-ethylhexyl) phthalate (DEHP) between 3 and 7 weeks of age. Post-puberty, i.e. at 6 months of age the effects on endocrinology and mating behavior were examined. The response to stimulation with a synthetic GnRH-analogue at 9 months of age resulted initially in lower concentration of LH in the exposed animals, compared to the control animals. We did not find any effects of DEHP on the mating behavior. Also, the effects of DEHP during the treatment period on the plasma concentrations of testosterone, oestradiol and LH were examined. During the exposure period there was a transient decrease in plasma concentrations of LH in the control group, which did not occur in the boars exposed to DEHR The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus-pituitary-gonadal axis. (c) 2005 Elsevier Inc. All rights reserved

Originalspråk	Engelska
Sidor (från-till)	160-166
Antal sidor	7
Tidskrift	Reproductive Toxicology
Volym	21
Nummer	2
DOI	https://doi.org/10.1016/j.reprotox.2005.07.012
Status	Publicerad - 2006

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10.1016/j.reprotox.2005.07.012

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@article{ce62295556374c20a84e2ba9a5470f6b,

title = "Ljungvall K, Spjuth L, Hulten F, Einarsson S, Rodriguez-Martinez H, Andersson K, Magnusson U. 2006",

abstract = "In a split-litter design experiment, boars were exposed orally three times weekly to 300 mg/kg of di(2-ethylhexyl) phthalate (DEHP) between 3 and 7 weeks of age. Post-puberty, i.e. at 6 months of age the effects on endocrinology and mating behavior were examined. The response to stimulation with a synthetic GnRH-analogue at 9 months of age resulted initially in lower concentration of LH in the exposed animals, compared to the control animals. We did not find any effects of DEHP on the mating behavior. Also, the effects of DEHP during the treatment period on the plasma concentrations of testosterone, oestradiol and LH were examined. During the exposure period there was a transient decrease in plasma concentrations of LH in the control group, which did not occur in the boars exposed to DEHR The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus-pituitary-gonadal axis. (c) 2005 Elsevier Inc. All rights reserved",

author = "Karl Ljungvall and Linda Spjuth and Fredrik Hulten and Stig Einarsson and Heriberto Rodriguez and Kjell Andersson and Ulf Magnusson",

year = "2006",

doi = "10.1016/j.reprotox.2005.07.012",

language = "English",

volume = "21",

pages = "160--166",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier Inc.",

number = "2",

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TY - JOUR

T1 - Ljungvall K, Spjuth L, Hulten F, Einarsson S, Rodriguez-Martinez H, Andersson K, Magnusson U. 2006

AU - Ljungvall, Karl

AU - Spjuth, Linda

AU - Hulten, Fredrik

AU - Einarsson, Stig

AU - Rodriguez, Heriberto

AU - Andersson, Kjell

AU - Magnusson, Ulf

PY - 2006

Y1 - 2006

N2 - In a split-litter design experiment, boars were exposed orally three times weekly to 300 mg/kg of di(2-ethylhexyl) phthalate (DEHP) between 3 and 7 weeks of age. Post-puberty, i.e. at 6 months of age the effects on endocrinology and mating behavior were examined. The response to stimulation with a synthetic GnRH-analogue at 9 months of age resulted initially in lower concentration of LH in the exposed animals, compared to the control animals. We did not find any effects of DEHP on the mating behavior. Also, the effects of DEHP during the treatment period on the plasma concentrations of testosterone, oestradiol and LH were examined. During the exposure period there was a transient decrease in plasma concentrations of LH in the control group, which did not occur in the boars exposed to DEHR The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus-pituitary-gonadal axis. (c) 2005 Elsevier Inc. All rights reserved

AB - In a split-litter design experiment, boars were exposed orally three times weekly to 300 mg/kg of di(2-ethylhexyl) phthalate (DEHP) between 3 and 7 weeks of age. Post-puberty, i.e. at 6 months of age the effects on endocrinology and mating behavior were examined. The response to stimulation with a synthetic GnRH-analogue at 9 months of age resulted initially in lower concentration of LH in the exposed animals, compared to the control animals. We did not find any effects of DEHP on the mating behavior. Also, the effects of DEHP during the treatment period on the plasma concentrations of testosterone, oestradiol and LH were examined. During the exposure period there was a transient decrease in plasma concentrations of LH in the control group, which did not occur in the boars exposed to DEHR The data suggest that DEHP in low repeated oral doses causes lasting effects on the hypothalamus-pituitary-gonadal axis. (c) 2005 Elsevier Inc. All rights reserved

UR - https://res.slu.se/id/publ/10183

U2 - 10.1016/j.reprotox.2005.07.012

DO - 10.1016/j.reprotox.2005.07.012

M3 - Journal article

C2 - 16171971

SN - 0890-6238

VL - 21

SP - 160

EP - 166

JO - Reproductive Toxicology

JF - Reproductive Toxicology

IS - 2

ER -