TY - JOUR
T1 - Identification of quantitative trait loci for production traits in commercial pig populations
AU - Evans, GJ
AU - Giuffra, E
AU - Sanchez, A
AU - Kerje, S
AU - Davalos, G
AU - Vidal, O
AU - Illán, S
AU - Noguera, JL
AU - Varona, L
AU - Velander, I
AU - Southwood, OI
AU - de Koning, DJ
AU - Haley, CS
AU - Plastow, GS
AU - Andersson, L
PY - 2003
Y1 - 2003
N2 - The aim of this study was to investigate methods for detecting QTL in outbred commercial pig populations. Several QTL for back fat and growth rate, previously detected in experimental resource populations, were examined for segregation in 10 different populations. Two hundred trait-by population-by chromosome tests were performed, resulting in 20 tests being significant at the 5% level. In addition, 53 QTL tests for 11 meat quality traits were declared significant, using a subset of the populations. These results show that a considerable amount of phenotypic variance observed in these populations can be explained by major alleles segregating at several of the loci described. Thus, despite a relatively strong selection pressure for growth and back fat traits in these populations, these alleles have not yet reached fixation. The approaches used here demonstrate that it is possible to verify segregation of QTL in commercial populations by limited genotyping of a selection of informative animals. Such verified QTL may be directly exploited in marker-assisted selection (MAS) programs in commercial populations and their molecular basis may be revealed by positional candidate cloning.
AB - The aim of this study was to investigate methods for detecting QTL in outbred commercial pig populations. Several QTL for back fat and growth rate, previously detected in experimental resource populations, were examined for segregation in 10 different populations. Two hundred trait-by population-by chromosome tests were performed, resulting in 20 tests being significant at the 5% level. In addition, 53 QTL tests for 11 meat quality traits were declared significant, using a subset of the populations. These results show that a considerable amount of phenotypic variance observed in these populations can be explained by major alleles segregating at several of the loci described. Thus, despite a relatively strong selection pressure for growth and back fat traits in these populations, these alleles have not yet reached fixation. The approaches used here demonstrate that it is possible to verify segregation of QTL in commercial populations by limited genotyping of a selection of informative animals. Such verified QTL may be directly exploited in marker-assisted selection (MAS) programs in commercial populations and their molecular basis may be revealed by positional candidate cloning.
UR - https://res.slu.se/id/publ/1704
U2 - 10.1093/genetics/164.2.621
DO - 10.1093/genetics/164.2.621
M3 - Journal article
C2 - 12807782
SN - 0016-6731
VL - 164
SP - 621
EP - 627
JO - Genetics
JF - Genetics
IS - 2
ER -