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Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study

  • Raul Zamora-Ros
  • , Veronika Fedirko
  • , Antonia Trichopoulou
  • , Carlos A. González
  • , Christina Bamia
  • , Elisabeth Trepo
  • , Ute Nöthlings
  • , Talita Duarte-Salles
  • , Mauro Serafini
  • , Lea Bredsdorff
  • , Kim Overvad
  • , Anne Tjønneland
  • , Jytte Halkjær
  • , Guy Fagherazzi
  • , Florence Perquier
  • , Marie-Christine Boutron-Ruault
  • , Verena Katzke
  • , Annekatrin Lukanova
  • , Anna Floegel
  • , Heiner Boeing
  • Pagona Lagiou, Dimitrios Trichopoulos, Saieva Calogero, Claudia Agnoli, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Elisabete Weiderpass, Dagrun Engeset, Guri Skeie, Marcial Vicente Argüelles, Esther Molina-Montes, Miren Dorronsora, María José Tormo, Eva Ardanaz, Ulrika Ericson, Emily Sonestedt, Malin Sund, Rikard Landberg, Kay-Thee Khaw, Nicholas J. Wareham, Francesca L. Crowe, Elio Riboli, Mazda Jenab

    Publikation: Bidrag till tidskriftArtikel i vetenskaplig tidskriftPeer review

    Sammanfattning

    What's new? Coffee, tea, fruits and vegetables, and certain other foods may protect against hepatocellular carcinoma (HCC), thanks to their antioxidant ingredients. This study lends fresh support to that idea, revealing specifically that dietary flavanols, which possess antioxidant activity, could play a favourable role in HCC prevention. Dietary antioxidant capacity from coffee intake in particular was found to be inversely associated with HCC risk, though statistical significance was lost after exclusion of the first two years of follow-up. Assessment of the bioavailability of flavonoids and other antioxidants is needed to confirm links between antioxidant intake and HCC risk.
    OriginalspråkEngelska
    Sidor (från-till)2429-2443
    Antal sidor15
    TidskriftInternational Journal of Cancer
    Volym133
    Nummer10
    DOI
    StatusPublicerad - 2013

    FN:s SDG:er

    Detta resultat bidrar till följande hållbara utvecklingsmål:

    1. SDG 3 – God hälsa och välbefinnande
      SDG 3 – God hälsa och välbefinnande

    Nyckelord

    • flavonoids
    • lignans
    • dietary intake
    • antioxidant capacity
    • hepatocellular carcinoma
    • EPIC

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