Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context

Alberto Celma; Svante Rehnstam; Paul Löffler; Karin Wiberg; Karl Lilja; Helene Ek Henning; Johan Gustafsson; Lina Wendt-Rasch

Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context

Alberto Celma
, Svante Rehnstam
, Paul Löffler
, Karin Wiberg
, Karl Lilja
, Helene Ek Henning
, Johan Gustafsson
, Lina Wendt-Rasch

Institutionen för vatten och miljö

Publikation: Bok/rapport/proceedings › Rapport › Forskning

29 Nedladdningar

Sammanfattning

Förutsättningslös (non-target) och bred, riktad (suspect) masspektrometri (MS)- screening (NTS och SS) av miljöföroreningar används i allt större utsträckning för att upptäcka ett brett spektrum av kemiska ämnen i exponerade matriser. Skillnader i förväntningar mellan tillsynsmyndigheter och forskare kan dock begränsa användningen av den information som erhålls genom sådana uppdragsstudier. Denna rapport sammanfattar resultaten av en workshop organiserad av Toxikologiska rådet (2024) som syftade till att förbättra samarbetet och anpassa förväntningarna mellan tillsynsmyndigheter och forskare involverade i NTS- och SS-studier. Deltagare från tillsynsmyndigheter, forskningsinstitutioner och andra intressenter identifierade viktiga utmaningar och rekommendationer i fyra steg av uppdragsstudier: projektdesign, implementering, rapportering och tolkning av resultat samt kommunikation efter projektet. Tidiga och transparenta diskussioner framhölls som viktiga för att tydligt definiera de regulatoriska frågeställningarna, fastställa realistiska förväntningar och avgöra om riktad analys (targeted analysis), SS eller NTS, alternativt en kombination av dessa, är den lämpligaste metodiken. Workshopen betonade också vikten av en kontinuerlig dialog under projektgenomförandet, robusta kvalitetssäkringsförfaranden, transparent rapportering av konfidensnivåer och detektionsgränser samt strategisk arkivering av analytiska data för framtida retrospektiv analys. Att stärka kommunikationen och anpassa förväntningar identifierades som viktiga steg för att öka det regulatoriska värdet av NTS och SS inom miljöövervakning och hantering av kemiska risker.

Originalspråk	Engelska
Förlag	Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences
Antal sidor	23
Status	Publicerad - 2026

Publikationsserier

Serie	Rapport / Sveriges lantbruksuniversitet, Institutionen för vatten och miljö
Numrering	2025:14

Nyckelord

HRMS
High Resolution Mass Spectrometry
Non-target screening
Regulatory – academic collaboration
Suspect screening

SLU-serie

Rapport (Institutionen för vatten och miljö)

Åtkomst av dokument

FulltextSlutlig publicerad version, 963 KBLicens: CC BY

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Celma, A., Rehnstam, S., Löffler, P., Wiberg, K., Lilja, K., Ek Henning, H., Gustafsson, J., & Wendt-Rasch, L. (2026). Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context. Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences. Rapport / Sveriges lantbruksuniversitet, Institutionen för vatten och miljö Nr. 2025:14

Celma, Alberto ; Rehnstam, Svante ; Löffler, Paul et al. / Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context. Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, 2026. 23 s. (Rapport / Sveriges lantbruksuniversitet, Institutionen för vatten och miljö; Nr. 2025:14).

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title = "Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context",

abstract = "Non-target and suspect mass spectrometry screening (NTS and SS) are increasingly used to detect a broad range of chemical contaminants in exposed matrices. However, differences in expectations between regulatory authorities and academic researchers can limit the effective use of the information obtained by such commissioned studies. This report summarizes the outcomes of a 2024 workshop organized by the Swedish Toxicological Council that aimed to improve collaboration and align expectations between regulators and researchers involved in NTS and SS projects.Participants from regulatory agencies, research institutions, and other stakeholders identified key challenges and recommendations across four stages of commissioned studies: project design, study implementation, reporting and interpretation of results, and post-project communication. Early and transparent discussions were highlighted as essential to clearly define regulatory questions, establish realistic expectations, and determine whether targeted analysis, SS or non-target screening, alternatively a combination of them, is the most appropriate approach.The workshop also emphasized the importance of continuous dialogue during project execution, robust quality assurance procedures, transparent reporting of confidence levels and detection limits, and the strategic archiving of analytical data for future retrospective analysis. Strengthening communication and aligning expectations were identified as key steps to enhance the regulatory value of NTS and SS in environmental monitoring and chemical risk management.",

keywords = "HRMS, High Resolution Mass Spectrometry, Non-target screening, Regulatory {\textendash} academic collaboration, Suspect screening, HRMS, High Resolution Mass Spectrometry, Non-target screening, Regulatory {\textendash} academic collaboration, Suspect screening",

author = "Alberto Celma and Svante Rehnstam and Paul L{\"o}ffler and Karin Wiberg and Karl Lilja and \{Ek Henning\}, Helene and Johan Gustafsson and Lina Wendt-Rasch",

year = "2026",

language = "English",

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Celma, A , Rehnstam, S , Löffler, P , Wiberg, K, Lilja, K, Ek Henning, H, Gustafsson, J & Wendt-Rasch, L 2026, Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context. Rapport / Sveriges lantbruksuniversitet, Institutionen för vatten och miljö, nr. 2025:14, Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences.

Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context. / Celma, Alberto ; Rehnstam, Svante ; Löffler, Paul et al.
Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, 2026. 23 s. (Rapport / Sveriges lantbruksuniversitet, Institutionen för vatten och miljö; Nr. 2025:14).

Publikation: Bok/rapport/proceedings › Rapport › Forskning

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T1 - Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context

AU - Celma, Alberto

AU - Rehnstam, Svante

AU - Löffler, Paul

AU - Wiberg, Karin

AU - Lilja, Karl

AU - Ek Henning, Helene

AU - Gustafsson, Johan

AU - Wendt-Rasch, Lina

PY - 2026

Y1 - 2026

N2 - Non-target and suspect mass spectrometry screening (NTS and SS) are increasingly used to detect a broad range of chemical contaminants in exposed matrices. However, differences in expectations between regulatory authorities and academic researchers can limit the effective use of the information obtained by such commissioned studies. This report summarizes the outcomes of a 2024 workshop organized by the Swedish Toxicological Council that aimed to improve collaboration and align expectations between regulators and researchers involved in NTS and SS projects.Participants from regulatory agencies, research institutions, and other stakeholders identified key challenges and recommendations across four stages of commissioned studies: project design, study implementation, reporting and interpretation of results, and post-project communication. Early and transparent discussions were highlighted as essential to clearly define regulatory questions, establish realistic expectations, and determine whether targeted analysis, SS or non-target screening, alternatively a combination of them, is the most appropriate approach.The workshop also emphasized the importance of continuous dialogue during project execution, robust quality assurance procedures, transparent reporting of confidence levels and detection limits, and the strategic archiving of analytical data for future retrospective analysis. Strengthening communication and aligning expectations were identified as key steps to enhance the regulatory value of NTS and SS in environmental monitoring and chemical risk management.

AB - Non-target and suspect mass spectrometry screening (NTS and SS) are increasingly used to detect a broad range of chemical contaminants in exposed matrices. However, differences in expectations between regulatory authorities and academic researchers can limit the effective use of the information obtained by such commissioned studies. This report summarizes the outcomes of a 2024 workshop organized by the Swedish Toxicological Council that aimed to improve collaboration and align expectations between regulators and researchers involved in NTS and SS projects.Participants from regulatory agencies, research institutions, and other stakeholders identified key challenges and recommendations across four stages of commissioned studies: project design, study implementation, reporting and interpretation of results, and post-project communication. Early and transparent discussions were highlighted as essential to clearly define regulatory questions, establish realistic expectations, and determine whether targeted analysis, SS or non-target screening, alternatively a combination of them, is the most appropriate approach.The workshop also emphasized the importance of continuous dialogue during project execution, robust quality assurance procedures, transparent reporting of confidence levels and detection limits, and the strategic archiving of analytical data for future retrospective analysis. Strengthening communication and aligning expectations were identified as key steps to enhance the regulatory value of NTS and SS in environmental monitoring and chemical risk management.

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KW - Regulatory – academic collaboration

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KW - Regulatory – academic collaboration

KW - Suspect screening

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BT - Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context

PB - Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences

ER -

Celma A , Rehnstam S , Löffler P , Wiberg K, Lilja K, Ek Henning H et al. Bridging the gap between regulatory agencies and academic research for non-target screening studies in a Swedish context. Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, 2026. 23 s. (Rapport / Sveriges lantbruksuniversitet, Institutionen för vatten och miljö; Nr. 2025:14).