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Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele

  • LJ Kennedy
  • , S Quarmby
  • , GM Happ
  • , A Barnes
  • , IK Ramsey
  • , RM Dixon
  • , B Catchpole
  • , C Rusbridge
  • , PA Graham
  • , NS Hillbertz
  • , C Roethel
  • , WJ Dodds
  • , NG Carmichael
  • , WER Ollier
  • , et al.

    Publikation: Bidrag till tidskriftArtikel i vetenskaplig tidskriftPeer review

    Sammanfattning

    Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.
    OriginalspråkEngelska
    Sidor (från-till)82-86
    Antal sidor5
    TidskriftTissue Antigens
    Volym68
    Nummer1
    DOI
    StatusPublicerad - 2006

    Nyckelord

    • DLA
    • dogs
    • hypothyroidism
    • MHC

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