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AA amyloid in human food chain is a possible biohazard

  • Anna Rising
  • , Paola Gherardi
  • , Gefei Chen
  • , Jan Johansson
  • , Marie E. Oskarsson
  • , Gunilla T. Westermark
  • , Per Westermark

    Publikation: Bidrag till tidskriftArtikel i vetenskaplig tidskriftPeer review

    1 Nedladdningar

    Sammanfattning

    AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid beta peptide, associated with Alzheimer's disease.
    OriginalspråkEngelska
    Artikelnummer21069
    Antal sidor5
    TidskriftScientific Reports
    Volym11
    Nummer1
    DOI
    StatusPublicerad - 2021

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