TY - JOUR
T1 - Systemic oxytocin treatment modulates glucocorticoid and mineralocorticoid receptor mRNA in the rat hippocampus
AU - Uvnäs-Moberg, Kerstin
AU - Pettersson, M
PY - 2003
Y1 - 2003
N2 - The present study investigated the effects of oxytocin treatment on hippocampal glucocorticoid receptors. Oxytocin (I mg/kg s.c.) was administered once a day for 5 days to male Sprague-Dawley rats. The animals were sacrificed I day after treatment and expression of glucocorticoid and mineralocorticoid receptor (GR and MR) mRNA in the dorsal hippocampus was measured with in situ hybridization. The oxytocin treatment decreased GR mRNA expression in CA I + 2 and the dentate gyrus (P < 0.05), tended to decrease GR mRNA expression in CA3 (P = 0.07), and increased MR mRNA expression in the dentate gyrus (P < 0.05). These findings demonstrate that systemic oxytocin treatment induces changes in the hippocampal glucocorticoid receptors. Thus, oxytocin may modulate the activity of the hypothalamic-pituitary-adrenal-axis also at the hippocampal level in rats. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
AB - The present study investigated the effects of oxytocin treatment on hippocampal glucocorticoid receptors. Oxytocin (I mg/kg s.c.) was administered once a day for 5 days to male Sprague-Dawley rats. The animals were sacrificed I day after treatment and expression of glucocorticoid and mineralocorticoid receptor (GR and MR) mRNA in the dorsal hippocampus was measured with in situ hybridization. The oxytocin treatment decreased GR mRNA expression in CA I + 2 and the dentate gyrus (P < 0.05), tended to decrease GR mRNA expression in CA3 (P = 0.07), and increased MR mRNA expression in the dentate gyrus (P < 0.05). These findings demonstrate that systemic oxytocin treatment induces changes in the hippocampal glucocorticoid receptors. Thus, oxytocin may modulate the activity of the hypothalamic-pituitary-adrenal-axis also at the hippocampal level in rats. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
KW - oxytocin
KW - mineralocorticoid receptor
KW - glucocorticoid receptor
KW - hypothalamic-pituitary-adrenal-axis
KW - in situ hybridization
KW - rat
KW - hippocampus
KW - oxytocin
KW - mineralocorticoid receptor
KW - glucocorticoid receptor
KW - hypothalamic-pituitary-adrenal-axis
KW - in situ hybridization
KW - rat
KW - hippocampus
UR - https://res.slu.se/id/publ/1346
U2 - 10.1016/S0304-3940(03)00334-3
DO - 10.1016/S0304-3940(03)00334-3
M3 - Journal article
C2 - 12759173
SN - 0304-3940
VL - 343
SP - 97
EP - 100
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -