TY - JOUR
T1 - Scientific Opinion on Flavouring Group Evaluation 74, Revision 4 (FGE.74Rev4): Consideration of aliphatic sulphides and thiols evaluated by JECFA (53rd and 61st meeting) structurally related to aliphatic and alicyclic mono‐, di‐, tri‐ and polysulphides with or without additional oxygenated functional groups from chemical group 20 evaluated by EFSA in FGE.08Rev5
AU - Silano, Vittorio
AU - Bolognesi, Claudia
AU - Castle, Laurence
AU - Chipman, Kevin
AU - Cravedi, Jean-Pierre
AU - Engel, Karl-Heinz
AU - Fowler, Paul
AU - Franz, Roland
AU - Grob, Konrad
AU - Gurtler, Rainer
AU - Husoy, Trine
AU - Karenlampi, Sirpa
AU - Milana, Maria Rosaria
AU - Pfaff, Karla
AU - Riviere, Gilles
AU - Srinivasan, Jannavi
AU - Pocas, Maria de Fatima Tavares
AU - Tlustos, Christina
AU - Wolfle, Detlef
AU - Zorn, Holger
AU - Benigni, Romualdo
AU - Brimer, Leon
AU - Mulder, Gerard
AU - Oskarsson, Agneta
AU - Svendsen, Camilla
AU - van Benthem, Jan
AU - Anastassiadou, Maria
AU - Saarma, Siiri
AU - Mennes, Wim
PY - 2018
Y1 - 2018
N2 - The Panelon Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present revision of this FGE is on the assessment of recently submitted toxicity data on methyl propyl trisulfide [FL-no: 12.020], being the representative for a group of seven additional flavouring substances: diallyl trisulfide [FL-no: 12.009], dimethyl trisulfide [FL-no: 12.013], dipropyl trisulfide [FL-no: 12.023], methyl allyl trisulfide [FL-no: 12.045], diallyl polysulfides [FL-no: 12.074], methyl ethyl trisulfide [FL-no: 12.155] and diisopropyl trisulphide [FL-no: 12.280]. Specifications have been provided for all substances. The Paneldecided that the 90-day study submitted for [FL-no: 12.020] can be considered only once it is clearly demonstrated that the material tested is representative of the material of commerce and that potential reaction products of the components are not of safety concern. Therefore, no conclusion on the safety of the eight flavouring substances [FL-no: 12.009, 12.013, 12.020, 12.023, 12.045, 12.074, 12.155 and 12.280] can be reached. For 2-methyl-4-oxopentane-2-thiol [FL-no: 12.169] and 2-mercapto-2-methylpentan-1-ol [FL-no: 12.241], additional subchronic toxicity data are required. The remaining nine substances [FL-no: 12.088, 12.179, 12.198, 12.212, 12.238, 12.239, 12.255, 12.257 and 12.291] in this FGE are not considered of safety concern under the intended conditions of use. (c) 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
AB - The Panelon Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The present revision of this FGE is on the assessment of recently submitted toxicity data on methyl propyl trisulfide [FL-no: 12.020], being the representative for a group of seven additional flavouring substances: diallyl trisulfide [FL-no: 12.009], dimethyl trisulfide [FL-no: 12.013], dipropyl trisulfide [FL-no: 12.023], methyl allyl trisulfide [FL-no: 12.045], diallyl polysulfides [FL-no: 12.074], methyl ethyl trisulfide [FL-no: 12.155] and diisopropyl trisulphide [FL-no: 12.280]. Specifications have been provided for all substances. The Paneldecided that the 90-day study submitted for [FL-no: 12.020] can be considered only once it is clearly demonstrated that the material tested is representative of the material of commerce and that potential reaction products of the components are not of safety concern. Therefore, no conclusion on the safety of the eight flavouring substances [FL-no: 12.009, 12.013, 12.020, 12.023, 12.045, 12.074, 12.155 and 12.280] can be reached. For 2-methyl-4-oxopentane-2-thiol [FL-no: 12.169] and 2-mercapto-2-methylpentan-1-ol [FL-no: 12.241], additional subchronic toxicity data are required. The remaining nine substances [FL-no: 12.088, 12.179, 12.198, 12.212, 12.238, 12.239, 12.255, 12.257 and 12.291] in this FGE are not considered of safety concern under the intended conditions of use. (c) 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
KW - flavourings
KW - FGE.08
KW - FGE.74
KW - JECFA
KW - sulphides
KW - thiols
KW - flavourings
KW - FGE.08
KW - FGE.74
KW - JECFA
KW - sulphides
KW - thiols
UR - https://res.slu.se/id/publ/96782
U2 - 10.2903/j.efsa.2018.5167
DO - 10.2903/j.efsa.2018.5167
M3 - Journal article
SN - 1831-4732
VL - 16
JO - EFSA Journal
JF - EFSA Journal
IS - 3
M1 - 5167
ER -