Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

Jonas Lannergård; Bengt Guss; M. Flock; J.-I. Flock; Å. Karlström

doi:10.1016/j.vaccine.2006.02.016

Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

Jonas Lannergård
, Bengt Guss
, M. Flock
, J.-I. Flock
, Å. Karlström

Publication: Contribution to journal › Journal article › peer-review

Abstract

A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4144-4151
Number of pages	8
Journal	Vaccine
Volume	24
Issue number	19
DOIs	https://doi.org/10.1016/j.vaccine.2006.02.016
Publication status	Published - 2006

Keywords

Streptococcus equi
strangles
vaccination
extra cellular proteins

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10.1016/j.vaccine.2006.02.016

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title = "Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse",

abstract = "A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved.",

keywords = "Streptococcus equi, strangles, vaccination, extra cellular proteins, Streptococcus equi, strangles, vaccination, extra cellular proteins",

author = "Jonas Lannerg{\aa}rd and Bengt Guss and M. Flock and J.-I. Flock and {\AA}. Karlstr{\"o}m",

year = "2006",

doi = "10.1016/j.vaccine.2006.02.016",

language = "English",

volume = "24",

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journal = "Vaccine",

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T1 - Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

AU - Lannergård, Jonas

AU - Guss, Bengt

AU - Flock, M.

AU - Flock, J.-I.

AU - Karlström, Å.

PY - 2006

Y1 - 2006

N2 - A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved.

AB - A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved.

KW - Streptococcus equi

KW - strangles

KW - vaccination

KW - extra cellular proteins

KW - Streptococcus equi

KW - strangles

KW - vaccination

KW - extra cellular proteins

UR - https://res.slu.se/id/publ/8170

U2 - 10.1016/j.vaccine.2006.02.016

DO - 10.1016/j.vaccine.2006.02.016

M3 - Journal article

C2 - 16580099

SN - 0264-410X

VL - 24

SP - 4144

EP - 4151

JO - Vaccine

JF - Vaccine

IS - 19

ER -

Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

Abstract

Keywords

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