Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

Janine Winkler; Ya Xu; Yun Yun Gong; Johanna Lindahl; Susanne Kersten; Sven Daenicke; Michael N. Routledge

doi:10.1007/s12550-019-00383-7

Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

Janine Winkler
, Ya Xu
, Yun Yun Gong
, Johanna Lindahl
, Susanne Kersten
, Sven Daenicke
, Michael N. Routledge

Publication: Contribution to journal › Journal article › peer-review

Abstract

The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Mycotoxin Research
Volume	36
Issue number	2
DOIs	https://doi.org/10.1007/s12550-019-00383-7
Publication status	Published - 2020
Externally published	Yes

Keywords

Aflatoxin-albumin adduct
Biomarker
Aflatoxin M-1
ELISA
Dairy cow

Access to Document

10.1007/s12550-019-00383-7

Cite this

@article{ae1a153f7e60478f962b59b60a3d68cc,

title = "Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows",

abstract = "The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.",

keywords = "Aflatoxin-albumin adduct, Biomarker, Aflatoxin M-1, ELISA, Dairy cow, Aflatoxin-albumin adduct, Biomarker, Aflatoxin M-1, ELISA, Dairy cow",

author = "Janine Winkler and Ya Xu and Gong, \{Yun Yun\} and Johanna Lindahl and Susanne Kersten and Sven Daenicke and Routledge, \{Michael N.\}",

year = "2020",

doi = "10.1007/s12550-019-00383-7",

language = "English",

volume = "36",

pages = "207--211",

journal = "Mycotoxin Research",

issn = "0178-7888",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

AU - Winkler, Janine

AU - Xu, Ya

AU - Gong, Yun Yun

AU - Lindahl, Johanna

AU - Kersten, Susanne

AU - Daenicke, Sven

AU - Routledge, Michael N.

PY - 2020

Y1 - 2020

N2 - The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.

AB - The aflatoxin (AF) albumin adduct is often used as a biomarker for aflatoxin exposure in humans. An ELISA method previously used for aflatoxin serum albumin in human blood was used to analyse bovine serum samples (n = 22) collected from dairy cattle during an aflatoxin mitigation study in Kenya. Albumin adduct data were compared with aflatoxin M-1 (AFM(1)) levels in corresponding milk samples from these cows. The concentration ranged from < LOD to 487.9 pg/mL for AFM(1) and < LOD and 96.3 pg/mg for aflatoxin-albumin. This study indicates that aflatoxin-albumin adducts could be used as a measure of chronic aflatoxin exposure in dairy cattle.

KW - Aflatoxin-albumin adduct

KW - Biomarker

KW - Aflatoxin M-1

KW - ELISA

KW - Dairy cow

KW - Aflatoxin-albumin adduct

KW - Biomarker

KW - Aflatoxin M-1

KW - ELISA

KW - Dairy cow

UR - https://res.slu.se/id/publ/105610

U2 - 10.1007/s12550-019-00383-7

DO - 10.1007/s12550-019-00383-7

M3 - Journal article

SN - 0178-7888

VL - 36

SP - 207

EP - 211

JO - Mycotoxin Research

JF - Mycotoxin Research

IS - 2

ER -

Preliminary study on the relationship between aflatoxin-bovine serum albumin adducts in blood and aflatoxin M1 levels in milk of dairy cows

Abstract

Keywords

Access to Document

Other files and links

Cite this