Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

Johan Lundqvist; Heidi Pekar; Agneta Oskarsson

doi:10.1016/j.toxicon.2016.12.012

Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

Publication: Contribution to journal › Journal article › peer-review

Abstract

Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	47-50
Number of pages	4
Journal	Toxicon
Volume	126
DOIs	https://doi.org/10.1016/j.toxicon.2016.12.012
Publication status	Published - 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 6 Clean Water and Sanitation

Keywords

Microcystins
Oxidative stress
Nrf2

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10.1016/j.toxicon.2016.12.012

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abstract = "Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.",

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AU - Lundqvist, Johan

AU - Pekar, Heidi

AU - Oskarsson, Agneta

PY - 2017

Y1 - 2017

N2 - Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.

AB - Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.

KW - Microcystins

KW - Oxidative stress

KW - Nrf2

KW - Microcystins

KW - Oxidative stress

KW - Nrf2

UR - https://res.slu.se/id/publ/88794

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DO - 10.1016/j.toxicon.2016.12.012

M3 - Journal article

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SN - 0041-0101

VL - 126

SP - 47

EP - 50

JO - Toxicon

JF - Toxicon

ER -

Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

Abstract

UN SDGs

Keywords

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