TY - JOUR
T1 - Markers of Borna disease virus infection in cats with staggering disease
AU - Wensman, Jonas Johansson
AU - Hultin Jäderlund, Karin
AU - Hagberg Gustavsson, Malin
AU - Hamlin, Helene
AU - Karlstam, Erika
AU - Lilliehöök, Inger
AU - Örde Öström, Inga-Lena
AU - Belák, Sándor
AU - Berg, Mikael
AU - Ström Holst, Bodil
PY - 2012
Y1 - 2012
N2 - Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.
AB - Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.
UR - https://res.slu.se/id/publ/57722
U2 - 10.1177/1098612X12446638
DO - 10.1177/1098612X12446638
M3 - Journal article
C2 - 22553310
SN - 1098-612X
VL - 14
SP - 573
EP - 582
JO - Journal of Feline Medicine and Surgery
JF - Journal of Feline Medicine and Surgery
IS - 8
ER -