Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs

Ren Sun; Liya Wang

doi:10.1186/1471-2180-13-184

Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs

Ren Sun
, Liya Wang

Publication: Contribution to journal › Journal article › peer-review

Abstract

Conclusion: We have shown that several anticancer and antiviral nucleoside and nucleobase analogs are potent inhibitors of Mpn growth and that the mechanism of inhibition are most likely due to inhibition of enzymes in the nucleotide biosynthesis pathway and nucleoside transporter. Our results suggest that enzymes in Mycoplasma nucleotide biosynthesis are potential targets for future design of antibiotics against Mycoplasma infection.

Original language	English
Article number	184
Number of pages	12
Journal	BMC Microbiology
Volume	13
DOIs	https://doi.org/10.1186/1471-2180-13-184
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mycoplasma pneumoniae
Growth inhibition
6-thioguanine
Trifluorothymidine
Hypoxanthine guanine phosphoribosyl transferase
Thymidine kinase

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10.1186/1471-2180-13-184

Cite this

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title = "Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs",

abstract = "Conclusion: We have shown that several anticancer and antiviral nucleoside and nucleobase analogs are potent inhibitors of Mpn growth and that the mechanism of inhibition are most likely due to inhibition of enzymes in the nucleotide biosynthesis pathway and nucleoside transporter. Our results suggest that enzymes in Mycoplasma nucleotide biosynthesis are potential targets for future design of antibiotics against Mycoplasma infection.",

keywords = "Mycoplasma pneumoniae, Growth inhibition, 6-thioguanine, Trifluorothymidine, Hypoxanthine guanine phosphoribosyl transferase, Thymidine kinase, Mycoplasma pneumoniae, Growth inhibition, 6-thioguanine, Trifluorothymidine, Hypoxanthine guanine phosphoribosyl transferase, Thymidine kinase",

author = "Ren Sun and Liya Wang",

year = "2013",

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language = "English",

volume = "13",

journal = "BMC Microbiology",

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T1 - Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs

AU - Sun, Ren

AU - Wang, Liya

PY - 2013

Y1 - 2013

N2 - Conclusion: We have shown that several anticancer and antiviral nucleoside and nucleobase analogs are potent inhibitors of Mpn growth and that the mechanism of inhibition are most likely due to inhibition of enzymes in the nucleotide biosynthesis pathway and nucleoside transporter. Our results suggest that enzymes in Mycoplasma nucleotide biosynthesis are potential targets for future design of antibiotics against Mycoplasma infection.

AB - Conclusion: We have shown that several anticancer and antiviral nucleoside and nucleobase analogs are potent inhibitors of Mpn growth and that the mechanism of inhibition are most likely due to inhibition of enzymes in the nucleotide biosynthesis pathway and nucleoside transporter. Our results suggest that enzymes in Mycoplasma nucleotide biosynthesis are potential targets for future design of antibiotics against Mycoplasma infection.

KW - Mycoplasma pneumoniae

KW - Growth inhibition

KW - 6-thioguanine

KW - Trifluorothymidine

KW - Hypoxanthine guanine phosphoribosyl transferase

KW - Thymidine kinase

KW - Mycoplasma pneumoniae

KW - Growth inhibition

KW - 6-thioguanine

KW - Trifluorothymidine

KW - Hypoxanthine guanine phosphoribosyl transferase

KW - Thymidine kinase

UR - https://res.slu.se/id/publ/55281

U2 - 10.1186/1471-2180-13-184

DO - 10.1186/1471-2180-13-184

M3 - Journal article

C2 - 23919755

SN - 1471-2180

VL - 13

JO - BMC Microbiology

JF - BMC Microbiology

M1 - 184

ER -

Inhibition of Mycoplasma pneumoniae growth by FDA-approved anticancer and antiviral nucleoside and nucleobase analogs

Abstract

UN SDGs

Keywords

Access to Document

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