TY - JOUR
T1 - High-throughput DNA sequence analysis elucidates novel insight into the genetic basis of adaptation in local sheep
AU - Asadollahpour Nanaei, Hojjat
AU - Amiri Ghanatsaman, Zeinab
AU - Farahvashi, Mohammad Ali
AU - Mousavi, Seyedeh Fatemeh
AU - Banabazi, Mohammad Hossein
AU - Asadi Fozi, Masood
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature B.V. 2024.
PY - 2024
Y1 - 2024
N2 - Understanding how evolutionary factors related to climate adaptation and human selection have influenced the genetic architecture of domesticated animals is of great interest in biology. In the current study, by using 304 whole genomes from different geographical regions (including Europe, north Africa, Southwest Asia, east Asia, west Africa, south Asia, east Africa, Australia and Turkey), We evaluate global sheep population dynamics in terms of genetic variation and population structure. We further conducted comparative population analysis to study the genetic underpinnings of climate adaption to local environments and also morphological traits. In order to identify genomic signals under selection, we applied fixation index (FST) and also nucleotide diversity (theta pi) statistical measurements. Our results revealed several candidate genes on different chromosomes under selection for local climate adaptation (e.g. HOXC12, HOXC13, IRF1, FGD2 and GNAQ), body size (PDGFA, HMGA2, PDE3A) and also morphological related traits (RXFP2). The discovered candidate genes may offer newel insights into genetic underpinning of regional adaptation and commercially significant features in local sheep.
AB - Understanding how evolutionary factors related to climate adaptation and human selection have influenced the genetic architecture of domesticated animals is of great interest in biology. In the current study, by using 304 whole genomes from different geographical regions (including Europe, north Africa, Southwest Asia, east Asia, west Africa, south Asia, east Africa, Australia and Turkey), We evaluate global sheep population dynamics in terms of genetic variation and population structure. We further conducted comparative population analysis to study the genetic underpinnings of climate adaption to local environments and also morphological traits. In order to identify genomic signals under selection, we applied fixation index (FST) and also nucleotide diversity (theta pi) statistical measurements. Our results revealed several candidate genes on different chromosomes under selection for local climate adaptation (e.g. HOXC12, HOXC13, IRF1, FGD2 and GNAQ), body size (PDGFA, HMGA2, PDE3A) and also morphological related traits (RXFP2). The discovered candidate genes may offer newel insights into genetic underpinning of regional adaptation and commercially significant features in local sheep.
KW - Candidate gene
KW - Genetic variation
KW - Local adaptation
KW - Sheep
KW - Whole genome
KW - Candidate gene
KW - Genetic variation
KW - Local adaptation
KW - Sheep
KW - Whole genome
UR - https://res.slu.se/id/publ/131206
U2 - 10.1007/s11250-024-04002-1
DO - 10.1007/s11250-024-04002-1
M3 - Journal article
C2 - 38691202
AN - SCOPUS:85191728645
SN - 0049-4747
VL - 56
JO - Tropical Animal Health and Production
JF - Tropical Animal Health and Production
IS - 4
M1 - 150
ER -