Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Lucas A. Smolders; Björn P. Meij; David Onis; Frank M. Riemers; Niklas Bergknut; Rickard Wubbolts; Guy C.M. Grinwis; Martin Houweling; Marian J.A. Groot Koerkamp; Dik van Lenen; Frank Holstege; H.A.W. Hazewinkel; LB Creemers; LC Penning; Marianna A. Tryfonidou

doi:10.1186/ar4157

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Lucas A. Smolders
, Björn P. Meij
, David Onis
, Frank M. Riemers
, Niklas Bergknut
, Rickard Wubbolts
, Guy C.M. Grinwis
, Martin Houweling
, Marian J.A. Groot Koerkamp
, Dik van Lenen
, Frank Holstege
, H.A.W. Hazewinkel
, LB Creemers
, LC Penning
, Marianna A. Tryfonidou

Publication: Contribution to journal › Journal article › peer-review

Abstract

Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.

Original language	English
Number of pages	19
Journal	Arthritis Research and Therapy
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/ar4157
Publication status	Published - 2013

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10.1186/ar4157

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Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R., Grinwis, G. C. M., Houweling, M., Groot Koerkamp, M. J. A., van Lenen, D., Holstege, F., Hazewinkel, H. A. W., Creemers, LB., Penning, LC., & Tryfonidou, M. A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research and Therapy, 15(1). https://doi.org/10.1186/ar4157

@article{89e4ccb2f2994704ac93f43ed2d0d60c,

title = "Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies",

abstract = "Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.",

author = "Smolders, \{Lucas A.\} and Meij, \{Bj{\"o}rn P.\} and David Onis and Riemers, \{Frank M.\} and Niklas Bergknut and Rickard Wubbolts and Grinwis, \{Guy C.M.\} and Martin Houweling and \{Groot Koerkamp\}, \{Marian J.A.\} and \{van Lenen\}, Dik and Frank Holstege and H.A.W. Hazewinkel and LB Creemers and LC Penning and Tryfonidou, \{Marianna A.\}",

year = "2013",

doi = "10.1186/ar4157",

language = "English",

volume = "15",

journal = "Arthritis Research and Therapy",

issn = "1478-6354",

publisher = "BioMed Central Ltd",

number = "1",

}

Smolders, LA, Meij, BP, Onis, D, Riemers, FM, Bergknut, N, Wubbolts, R, Grinwis, GCM, Houweling, M, Groot Koerkamp, MJA, van Lenen, D, Holstege, F, Hazewinkel, HAW, Creemers, LB, Penning, LC & Tryfonidou, MA 2013, 'Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies', Arthritis Research and Therapy, vol. 15, no. 1. https://doi.org/10.1186/ar4157

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. / Smolders, Lucas A.; Meij, Björn P.; Onis, David et al.
In: Arthritis Research and Therapy, Vol. 15, No. 1, 2013.

Publication: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

AU - Smolders, Lucas A.

AU - Meij, Björn P.

AU - Onis, David

AU - Riemers, Frank M.

AU - Bergknut, Niklas

AU - Wubbolts, Rickard

AU - Grinwis, Guy C.M.

AU - Houweling, Martin

AU - Groot Koerkamp, Marian J.A.

AU - van Lenen, Dik

AU - Holstege, Frank

AU - Hazewinkel, H.A.W.

AU - Creemers, LB

AU - Penning, LC

AU - Tryfonidou, Marianna A.

PY - 2013

Y1 - 2013

N2 - Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.

AB - Conclusions: Early IVD degeneration involves down-regulation of canonical Wnt signaling and Caveolin-1 expression, which appears to be essential to the physiology and preservation of NCs. Therefore, Caveolin-1 may be regarded an exciting target for developing strategies for IVD regeneration.

UR - https://res.slu.se/id/publ/50356

U2 - 10.1186/ar4157

DO - 10.1186/ar4157

M3 - Journal article

C2 - 23360510

SN - 1478-6354

VL - 15

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

IS - 1

ER -

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Abstract

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