Fine-mapping of a candidate region associated with milk-fat composition on Bos Taurus Autosome 17

Sandrine Duchemin; M.H.P.W. Visker; J.A.M. Van Arendonk; Henk Bovenhuis

Fine-mapping of a candidate region associated with milk-fat composition on Bos Taurus Autosome 17

Sandrine Duchemin
, M.H.P.W. Visker
, J.A.M. Van Arendonk
, Henk Bovenhuis

Publication: Contribution to conference › Conference poster

Abstract

A genomic region associated with milk-fat composition has been detected on BTA17. However, no candidate gene or causal variant has been identified so far. Our goal was to fine-map this region by using imputed 777k SNP genotypes. Phenotypes and genotypes were available on 1,581 animals. Phenotypes consisted of gas chromatography measurements of C8:0, and genotypes consisted of the imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. Based on these SNP, haplotypes were constructed. Haplotypes suggested the presence of one QTL within the fine-mapped region. This QTL explained 9% of the genetic variation in C8:0. Although many genes are present in this QTL region, most of these genes have not been characterized yet. Therefore, no clear candidate gene associated with milk-fat composition could be identified.

Original language	English
Number of pages	3
Publication status	Published - 2014
Event	10th World Congress of Genetics Applied to Livestock Production - Vancouver, BC, Canada Duration: 1 Jan 2014 → …

Conference

Conference	10th World Congress of Genetics Applied to Livestock Production
City	Vancouver, BC, Canada
Period	2014-01-01 → …

Cite this

@conference{33a56cb272a64d30b345fe75f1934570,

title = "Fine-mapping of a candidate region associated with milk-fat composition on Bos Taurus Autosome 17",

abstract = "A genomic region associated with milk-fat composition has been detected on BTA17. However, no candidate gene or causal variant has been identified so far. Our goal was to fine-map this region by using imputed 777k SNP genotypes. Phenotypes and genotypes were available on 1,581 animals. Phenotypes consisted of gas chromatography measurements of C8:0, and genotypes consisted of the imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. Based on these SNP, haplotypes were constructed. Haplotypes suggested the presence of one QTL within the fine-mapped region. This QTL explained 9\% of the genetic variation in C8:0. Although many genes are present in this QTL region, most of these genes have not been characterized yet. Therefore, no clear candidate gene associated with milk-fat composition could be identified.",

author = "Sandrine Duchemin and M.H.P.W. Visker and \{Van Arendonk\}, J.A.M. and Henk Bovenhuis",

year = "2014",

language = "English",

note = "10th World Congress of Genetics Applied to Livestock Production ; Conference date: 01-01-2014",

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TY - CONF

T1 - Fine-mapping of a candidate region associated with milk-fat composition on Bos Taurus Autosome 17

AU - Duchemin, Sandrine

AU - Visker, M.H.P.W.

AU - Van Arendonk, J.A.M.

AU - Bovenhuis, Henk

PY - 2014

Y1 - 2014

N2 - A genomic region associated with milk-fat composition has been detected on BTA17. However, no candidate gene or causal variant has been identified so far. Our goal was to fine-map this region by using imputed 777k SNP genotypes. Phenotypes and genotypes were available on 1,581 animals. Phenotypes consisted of gas chromatography measurements of C8:0, and genotypes consisted of the imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. Based on these SNP, haplotypes were constructed. Haplotypes suggested the presence of one QTL within the fine-mapped region. This QTL explained 9% of the genetic variation in C8:0. Although many genes are present in this QTL region, most of these genes have not been characterized yet. Therefore, no clear candidate gene associated with milk-fat composition could be identified.

AB - A genomic region associated with milk-fat composition has been detected on BTA17. However, no candidate gene or causal variant has been identified so far. Our goal was to fine-map this region by using imputed 777k SNP genotypes. Phenotypes and genotypes were available on 1,581 animals. Phenotypes consisted of gas chromatography measurements of C8:0, and genotypes consisted of the imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. Based on these SNP, haplotypes were constructed. Haplotypes suggested the presence of one QTL within the fine-mapped region. This QTL explained 9% of the genetic variation in C8:0. Although many genes are present in this QTL region, most of these genes have not been characterized yet. Therefore, no clear candidate gene associated with milk-fat composition could be identified.

UR - https://res.slu.se/id/publ/63395

M3 - Conference poster

T2 - 10th World Congress of Genetics Applied to Livestock Production

Y2 - 1 January 2014

ER -

Fine-mapping of a candidate region associated with milk-fat composition on Bos Taurus Autosome 17

Abstract

Conference

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