Epistasis and the release of genetic variation during long-term selection

Lina Strömstedt; Leif Andersson; P Åhgren; Örjan Carlborg; P B Siegel; Örjan Carlborg

doi:10.1038/ng1761

Epistasis and the release of genetic variation during long-term selection

Lina Strömstedt
, Leif Andersson
, P Åhgren
, Örjan Carlborg
, P B Siegel
, Örjan Carlborg

Publication: Contribution to journal › Journal article › peer-review

Abstract

It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.

Original language	English
Pages (from-to)	418-420
Number of pages	3
Journal	Nature Genetics
Volume	38
Issue number	4
DOIs	https://doi.org/10.1038/ng1761
Publication status	Published - 2006

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abstract = "It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.",

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AU - Siegel, P B

AU - Carlborg, Örjan

PY - 2006

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AB - It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.

UR - https://res.slu.se/id/publ/10481

U2 - 10.1038/ng1761

DO - 10.1038/ng1761

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JO - Nature Genetics

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Epistasis and the release of genetic variation during long-term selection

Abstract

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