DNA-sequence-specific erasers of epigenetic memory

Iva Mozgova; Claudia Köhler

doi:10.1038/ng.3579

DNA-sequence-specific erasers of epigenetic memory

Iva Mozgova
, Claudia Köhler

Department of Plant Biology

Publication: Other publication › Research › peer-review

Abstract

How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatinmodifying complex.

Original language	English
Number of pages	2
Volume	48
DOIs	https://doi.org/10.1038/ng.3579
Publication status	Published - 2016

Publication series

Series	Nature Genetics
Number	6
Volume	48
ISSN	1061-4036

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AB - How epigenetic regulators find their specific targets remains a challenging question. Two parallel studies show that REF6, a plant H3K27me3 demethylase, binds a specific DNA motif via its zinc-finger domains and recruits the SWI/SNF-type ATPase BRAHMA, demonstrating a sequence-specific recruitment mechanism for a chromatinmodifying complex.

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DNA-sequence-specific erasers of epigenetic memory

Abstract

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