@article{935cce546da244eea63fb642bee4c55e,
title = "Discovery of 4 '-azido-2 '-deoxy-2 '-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication",
abstract = "4'-Azido-2'-deoxy-2'-methylcytidine (14) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC50 value of 1.2 mu M and showing moderate in vivo bioavailability in rat (F = 14\%). Here we describe the synthesis and biological evaluation of 4'-azido-2'-deoxy-2'-methylcytidine and prodrug derivatives thereof. (C) 2012 Elsevier Ltd. All rights reserved.",
keywords = "Hepatitis C virus, NS5B polymerase, Antivirals, Nucleoside, Prodrug, Phosphoramidate, Hepatitis C virus, NS5B polymerase, Antivirals, Nucleoside, Prodrug, Phosphoramidate",
author = "Genadiy Kalayanov and Anna Winqvist and Pedro Pinho and Christian Sund and Xiao-Xiong Zhou and Horst Wahling and Anna-Karin Belfrage and Michael Pelcman and Tatiana Agback and Kurt Benckestock and Kristina Wikstrom and Mirva Boothee and Anneli Lindqvist and Christina Rydegard and Jonckers, \{Tim H. M.\} and Koen Vandyck and Pierre Raboisson and Tse-I Lin and Sophie Lachau-Durand and \{de Kock\}, Herman and Smith, \{David B.\} and Martin, \{Joseph A.\} and Klaus Klumpp and Kenneth Simmen and Lotta Vrang and Ylva Terelius and Bertil Samuelsson and Asa Rosenquist and Johansson, \{Nils Gunnar\}",
year = "2012",
doi = "10.1016/j.bmcl.2012.03.021",
language = "English",
volume = "22",
pages = "3265--3268",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd",
number = "9",
}