TY - JOUR
T1 - Bone Morphogenetic Protein-2 Delivered by Hyaluronan-Based hydrogel Induces Massive Bone Formation and Healing of Cranial Defects in Minipigs
AU - Docherty-Skogh, Ann-Charlott
AU - Jensen Waern, Marianne
AU - Bergman, Kristoffer
AU - Ekman, Stina
AU - Hultenby, Kjell
AU - Ossipov, Dimitri
AU - Hilborn, Jöns
AU - Bowden, Tim
AU - Engstrand, Thomas
PY - 2010
Y1 - 2010
N2 - Reconsruction of large craniofacial bone defects is a challenge using bone transplants of alloplastic materials. The use of bone morphogenetic protein (BMP)-2 together with a suitable carrier is an attractive option that may facilitate new bone formation. The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nonparticles in the precence of BMP-2
AB - Reconsruction of large craniofacial bone defects is a challenge using bone transplants of alloplastic materials. The use of bone morphogenetic protein (BMP)-2 together with a suitable carrier is an attractive option that may facilitate new bone formation. The authors have developed a hydrogel that is formed in situ by the cross-linking of multifunctional hyaluronic acid and polyvinyl alcohol derivatives mixed with hydroxyapatite nonparticles in the precence of BMP-2
UR - https://res.slu.se/id/publ/29372
U2 - 10.1097/PRS.0b013e3181d629dc
DO - 10.1097/PRS.0b013e3181d629dc
M3 - Journal article
C2 - 20440158
SN - 0032-1052
VL - 125
SP - 1383
EP - 1392
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
IS - 5
ER -