TY - JOUR
T1 - Blood concentrations of amino acids, glucose and lactate during experimental swine dysentery
AU - Kruse, Robert
AU - Essen-Gustavsson, Birgitta
AU - Jensen Waern, Marianne
PY - 2007
Y1 - 2007
N2 - The aim of this study was to examine blood concentrations of amino acids, glucose and lactate in association with experimental swine dysentery. Ten pigs (similar to 23 kg) were orally inoculated with Brachyspira hyodysenteriae. Eight animals developed muco-haemorrhagic diarrhoea with impaired general appearance, changes in white blood cell counts and increased levels of the acute phase protein Serum Amyolid A. Blood samples were taken before inoculation, during the incubation period, during clinical signs of dysentery and during recovery. Neither plasma glucose nor lactate concentrations changed during the course of swine dysentery, but the serum concentrations of gluconeogenic non-essential amino acids decreased during dysentery. This was mainly due to decreases in alanine, glutamine, serine and tyrosine. Lysine increased during dysentery and at the beginning of the recovery period, and leucine increased during recovery. Glutamine, alanine and tyrosine levels show negative correlations with the numbers of neutrophils and monocytes. In conclusion, swine dysentery altered the blood concentrations of amino acids, but not of glucose or lactate. (C) 2006 Elsevier Ltd. All rights reserved.
AB - The aim of this study was to examine blood concentrations of amino acids, glucose and lactate in association with experimental swine dysentery. Ten pigs (similar to 23 kg) were orally inoculated with Brachyspira hyodysenteriae. Eight animals developed muco-haemorrhagic diarrhoea with impaired general appearance, changes in white blood cell counts and increased levels of the acute phase protein Serum Amyolid A. Blood samples were taken before inoculation, during the incubation period, during clinical signs of dysentery and during recovery. Neither plasma glucose nor lactate concentrations changed during the course of swine dysentery, but the serum concentrations of gluconeogenic non-essential amino acids decreased during dysentery. This was mainly due to decreases in alanine, glutamine, serine and tyrosine. Lysine increased during dysentery and at the beginning of the recovery period, and leucine increased during recovery. Glutamine, alanine and tyrosine levels show negative correlations with the numbers of neutrophils and monocytes. In conclusion, swine dysentery altered the blood concentrations of amino acids, but not of glucose or lactate. (C) 2006 Elsevier Ltd. All rights reserved.
KW - Brachyspira hyodysenteriae
KW - metabolism
KW - glutamine
KW - alanine
KW - lysine
KW - infection
KW - Brachyspira hyodysenteriae
KW - metabolism
KW - glutamine
KW - alanine
KW - lysine
KW - infection
UR - https://res.slu.se/id/publ/9599
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWR-4M7K9YW-1&_user=651610&_coverDate=06%2F30%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000035238&_version=1&_urlVersion=0&_userid=651610&md5=e969934ef09f7fdedf1ecab379ee8766
U2 - 10.1016/j.rvsc.2006.08.005
DO - 10.1016/j.rvsc.2006.08.005
M3 - Journal article
C2 - 17078986
SN - 0034-5288
VL - 82
SP - 323
EP - 331
JO - Research in Veterinary Science
JF - Research in Veterinary Science
IS - 3
ER -