Abstract
Models for repeated measures cross-over designs are defined in terms of growth curve models. In the paper two specific cross-over designs, called the AB:BA and ABAB:BABA design, are studied. The maximum likelihood estimators for the parameters are derived by utilizing the theory for growth curve models. A model with a structured dispersion matrix is defined for the AB:BA design, and a specific linear transformation is used to derive estimators in a convenient way. To illustrate numerically, maximum likelihood estimates are calculated for an ABAB:BABA study
| Original language | English |
|---|---|
| Pages (from-to) | 475-497 |
| Number of pages | 23 |
| Journal | Journal of Statistical Planning and Inference |
| Volume | 136 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2006 |
Keywords
- Cross-over desigh
- growth curve models
- repeated measurements
- maximum likelihood estimator
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