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AA amyloid in human food chain is a possible biohazard

  • Anna Rising
  • , Paola Gherardi
  • , Gefei Chen
  • , Jan Johansson
  • , Marie E. Oskarsson
  • , Gunilla T. Westermark
  • , Per Westermark

    Publication: Contribution to journalJournal articlepeer-review

    Abstract

    AA amyloidosis can be transmitted experimentally in several mammalian and avian species as well as spontaneously between captive animals, even by oral intake of amyloid seeds. Amyloid seeding can cross species boundaries, and fibrils of one kind of amyloid protein may also seed other types. Here we show that meat from Swedish and Italian cattle for consumption by humans often contains AA amyloid and that bovine AA fibrils efficiently cross-seed human amyloid beta peptide, associated with Alzheimer's disease.
    Original languageEnglish
    Article number21069
    Number of pages5
    JournalScientific Reports
    Volume11
    Issue number1
    DOIs
    Publication statusPublished - 2021

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