A MATHEMATICAL MODEL OF HUMAN THYMIDINE KINASE 2 ACTIVITY

Tomas Radivoyevitch; Birgitte Munch-Petersen; Liya Wang; Staffan Eriksson

doi:10.1080/15257770.2011.563765

A MATHEMATICAL MODEL OF HUMAN THYMIDINE KINASE 2 ACTIVITY

Tomas Radivoyevitch
, Birgitte Munch-Petersen
, Liya Wang
, Staffan Eriksson

Publication: Contribution to journal › Journal article › peer-review

Abstract

The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

Original language	English
Pages (from-to)	203-209
Number of pages	7
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	30
Issue number	3
DOIs	https://doi.org/10.1080/15257770.2011.563765
Publication status	Published - 2011

Keywords

Thymidine kinase 2
mathematical model

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10.1080/15257770.2011.563765

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title = "A MATHEMATICAL MODEL OF HUMAN THYMIDINE KINASE 2 ACTIVITY",

abstract = "The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.",

keywords = "Thymidine kinase 2, mathematical model, Thymidine kinase 2, mathematical model",

author = "Tomas Radivoyevitch and Birgitte Munch-Petersen and Liya Wang and Staffan Eriksson",

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AU - Radivoyevitch, Tomas

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AU - Wang, Liya

AU - Eriksson, Staffan

PY - 2011

Y1 - 2011

N2 - The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

AB - The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

KW - Thymidine kinase 2

KW - mathematical model

KW - Thymidine kinase 2

KW - mathematical model

UR - https://res.slu.se/id/publ/57735

U2 - 10.1080/15257770.2011.563765

DO - 10.1080/15257770.2011.563765

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JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 3

ER -

A MATHEMATICAL MODEL OF HUMAN THYMIDINE KINASE 2 ACTIVITY

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Keywords

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