A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Eleanor Raffan; Rowena J. Dennis; Conor J. O'Donovan; Julia M. Becker; Robert A. Scott; Stephen P. Smith; David J. Withers; Claire J. Wood; Elena Conci; Dylan N. Clements; Kim M. Summers; Alexander J. German; Cathryn S. Mellersh; Maja L. Arendt; Valentine P. Iyemere; Elaine Withers; Josefin Soder; Sara Wernersson; Goran Andersson; Kerstin Lindblad-Toh; Giles S. H. Yeo; Stephen O'Rahilly

doi:10.1016/j.cmet.2016.04.012

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Eleanor Raffan
, Rowena J. Dennis
, Conor J. O'Donovan
, Julia M. Becker
, Robert A. Scott
, Stephen P. Smith
, David J. Withers
, Claire J. Wood
, Elena Conci
, Dylan N. Clements
, Kim M. Summers
, Alexander J. German
, Cathryn S. Mellersh
, Maja L. Arendt
, Valentine P. Iyemere
, Elaine Withers
, Josefin Soder
, Sara Wernersson
, Goran Andersson
, Kerstin Lindblad-Toh

Giles S. H. Yeo, Stephen O'Rahilly

Publication: Contribution to journal › Journal article › peer-review

Abstract

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and b-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

Original language	English
Pages (from-to)	893-900
Number of pages	8
Journal	Cell Metabolism
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2016.04.012
Publication status	Published - 2016

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Raffan, E., Dennis, R. J., O'Donovan, C. J., Becker, J. M., Scott, R. A., Smith, S. P., Withers, D. J., Wood, C. J., Conci, E., Clements, D. N., Summers, K. M., German, A. J., Mellersh, C. S., Arendt, M. L., Iyemere, V. P., Withers, E., Soder, J., Wernersson, S., Andersson, G., ... O'Rahilly, S. (2016). A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs. Cell Metabolism, 23(5), 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

@article{d26aa4fe759c4b09811afca1563322c1,

title = "A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs",

abstract = "Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12\%. The deletion disrupts the b-MSH and b-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.",

author = "Eleanor Raffan and Dennis, \{Rowena J.\} and O'Donovan, \{Conor J.\} and Becker, \{Julia M.\} and Scott, \{Robert A.\} and Smith, \{Stephen P.\} and Withers, \{David J.\} and Wood, \{Claire J.\} and Elena Conci and Clements, \{Dylan N.\} and Summers, \{Kim M.\} and German, \{Alexander J.\} and Mellersh, \{Cathryn S.\} and Arendt, \{Maja L.\} and Iyemere, \{Valentine P.\} and Elaine Withers and Josefin Soder and Sara Wernersson and Goran Andersson and Kerstin Lindblad-Toh and Yeo, \{Giles S. H.\} and Stephen O'Rahilly",

year = "2016",

doi = "10.1016/j.cmet.2016.04.012",

language = "English",

volume = "23",

pages = "893--900",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "5",

}

Raffan, E, Dennis, RJ, O'Donovan, CJ, Becker, JM, Scott, RA, Smith, SP, Withers, DJ, Wood, CJ, Conci, E, Clements, DN, Summers, KM, German, AJ, Mellersh, CS, Arendt, ML, Iyemere, VP, Withers, E, Soder, J , Wernersson, S , Andersson, G, Lindblad-Toh, K, Yeo, GSH & O'Rahilly, S 2016, 'A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs', Cell Metabolism, vol. 23, no. 5, pp. 893-900. https://doi.org/10.1016/j.cmet.2016.04.012

TY - JOUR

T1 - A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

AU - Raffan, Eleanor

AU - Dennis, Rowena J.

AU - O'Donovan, Conor J.

AU - Becker, Julia M.

AU - Scott, Robert A.

AU - Smith, Stephen P.

AU - Withers, David J.

AU - Wood, Claire J.

AU - Conci, Elena

AU - Clements, Dylan N.

AU - Summers, Kim M.

AU - German, Alexander J.

AU - Mellersh, Cathryn S.

AU - Arendt, Maja L.

AU - Iyemere, Valentine P.

AU - Withers, Elaine

AU - Soder, Josefin

AU - Wernersson, Sara

AU - Andersson, Goran

AU - Lindblad-Toh, Kerstin

AU - Yeo, Giles S. H.

AU - O'Rahilly, Stephen

PY - 2016

Y1 - 2016

N2 - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and b-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

AB - Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and b-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

UR - https://res.slu.se/id/publ/79797

U2 - 10.1016/j.cmet.2016.04.012

DO - 10.1016/j.cmet.2016.04.012

M3 - Journal article

C2 - 27157046

SN - 1550-4131

VL - 23

SP - 893

EP - 900

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Abstract

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